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The route from Southampton to Luton is served daily by 78 bus departing from the stations of Southampton Coach Station, Southampton University Of Southampton, University Of Southampton and arriving to the stations of Luton Town, London Luton Airport, Luton Challney Near Travelodge, Luton, Challney (near Travelodge) Bus Stop.
The average duration of the journey is 4 h 49 min. The first bus leaves at 03:30. The last is at 21:55.

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