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The route from Rome to Brussels is served daily by 23 bus departing from the stations of Rome Tiburtina Bus Station, Via Teodorico, Rome Tiburtina and arriving to the stations of Brussels-North Station, Brussels South (Gare Du Midi), Gare Du Nord, Gare Du Midi, Brussels Midi / Brussel Zuid East, Brussels North Train Station.
The average duration of the journey is 30 h 22 min. The first bus leaves at 07:55. The last is at 22:30.

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