If the offers provided by buses do not suit your needs, trains and carpooling could represent a good alternative for this distance.
With such a long journey, we would like to give you some advice: you can look for a flight to Rome, or if your budget is limited, you can check night buses and trains to save the daytime for your visits.
When are the buses of the line Prague - Rome scheduled?
To get to Rome from Prague by bus, it will take you around 37 hours and 41 minutes, or even 26 hours and 35 minutes if you choose the fastest solutions. The first bus leaves Prague at 16:01, while the last one is at 20:01.
Which bus companies are in service in the route Prague - Rome?
There are many companies cooperating with virail, among which also FlixBus, Eurolines SA and Eurolines with buses to Rome.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.
Eurolines is one of the leader bus companies in Europe, with more than 350 connections in 23 countries. Among its services you can also find long-distance night buses.