If the offers provided by buses do not suit your needs, trains and carpooling could represent a good alternative for this distance.
When are the buses of the line Prague - Karlovy Vary scheduled?
The first bus to Karlovy Vary leaves at 08:03, while the last one is scheduled at 18:03. The journey takes on average 2 hours and 7 minutes, but the fastest connections take only 2 hours and 5 minutes.
By bus from Prague to Karlovy Vary: which companies offer the service?
Among the several partners of virail, you can also find FlixBus, offering buses from Prague to Karlovy Vary.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.