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The route from Birmingham to Southampton is served daily by 101 bus departing from the stations of Birmingham Airport Bus Station, Bearwood, Birmingham Bearwood, Birmingham Great Barr, Great Barr, Birmingham Coach Station, Coach Station, Birmingham Five Ways, Five Ways, BHM Airport and arriving to the stations of Southampton Coach Station, University Of Southampton, Southampton University Of Southampton.
The average duration of the journey is 6 h 33 min. The first bus leaves at 03:35. The last is at 23:20.

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