Seen the short distance between Rome and Prague, you could also choose to travel by train or carpooling. Spending little more money, your journey would become more comfortable.
Despite being extremely cheap, the bus is also very slow and getting from Rome to Prague by bus will take you a while. You could consider travelling by plane, getting low-cost tickets if you can book in advance.
When do the first and last buses from Rome to Prague leave?
The first bus to Prague leaves at 09:07, while the last one is scheduled at 23:07. The journey takes on average 21 hours and 51 minutes, but the fastest connections take only 20 hours and 10 minutes.
Which bus companies serve the route Rome - Prague?
There are many companies cooperating with virail, among which also FlixBus with buses to Prague.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.