If the offers provided by buses do not suit your needs, trains and carpooling could represent a good alternative for this distance.
Despite being extremely cheap, the bus is also very slow and getting from Milan to Cologne by bus will take you a while. You could consider travelling by plane, getting low-cost tickets if you can book in advance.
When do the first and last buses from Milan to Cologne leave?
The average duration of the journey is 14 hours and 50 minutes, but the fastest bus connections get you to Cologne in 12 hours and 55 minutes. The first bus is scheduled at 08:03 and the last one at 23:03.
Which bus lines can take you from Milan to Cologne?
There are many companies cooperating with virail, among which also FlixBus with buses to Cologne.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.