For such long distances, travelling by bus could not be the best solution. Check out alternatives by plane: with some luck, you will find low-cost tickets from Brussels to Madrid and be a lot faster!
What time do the busses to Madrid leave?
To get to Madrid from Brussels by bus, it will take you around 23 hours and 47 minutes, or even 21 hours if you choose the fastest solutions. The first bus leaves Brussels at 07:10, while the last one is at 11:10.
Which bus companies serve the route Brussels - Madrid?
There are many companies cooperating with virail, among which also FlixBus, Ouibus, ALSA and Eurolines with buses to Madrid.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.