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The route from Brussels to Madrid is served daily by 35 bus departing from the stations of Gare Du Midi, Brussels South (Gare Du Midi), Brussels North Train Station, Brussels Midi / Brussel Zuid East, Gare Du Nord, Brussels-North Station and arriving to the stations of Estación Sur - Mendez Alvaro, Estación Sur, Avenida De América Metro, Madrid, Madrid Mendez Alvaro Estacion Sur.
The average duration of the journey is 26 h 15 min. The first bus leaves at 07:30. The last is at 16:30.

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