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The route from Rome to Milan is served daily by 50 trains leaving from from the stations of Roma Ostiense, Roma Termini, Roma Tiburtina and arriving at in the stations of Milano Centrale, Milano Porta Garibaldi, Milano Rogoredo.
The average journey duration is 3 h 27 min. The first train leaves at 00:11. The last one is at 23:55.

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