If you are flexible with your travel dates, always consider that you can buy extremely cheap train tickets if you avoid travelling in the weekends and if you choose to travel during the low season.
If the train timetable doesn't fit in your schedule or budget, bus and carpooling can provide you some time and price alternatives, without substantially changing the duration of the journey.
What are the departure and arrival stations in Pilsen and Prague?
The trains to Prague will leave from Plzeň Hl.n. and will arrive at Praha Hl.n..
How long does it take from Pilsen to Prague and when do the trains leave?
With the fastest connections you will be in Prague in 1 hour and 30 minutes, but on average it takes 1 hour and 45 minutes. The first train headed to Prague is at 14:04, while the last one leaves Pilsen at 22:04.