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The route from Stoke-on-Trent to Manchester is served daily by 29 bus departing from the stations of Stoke-on-Trent Hanley, Stoke-on-Trent (Hanley Bus Station, Stands A & B), Stoke On Trent Central Train Station, Staffordshire University, Stoke-on-Trent and arriving to the stations of Manchester Airport Bus Station, Manchester Central Bus Station, Manchester Miles Platting, Manchester Coach Station.
The average duration of the journey is 1 h 25 min. The first bus leaves at 10:20. The last is at 23:35.

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