If the offers provided by buses do not suit your needs, trains and carpooling could represent a good alternative for this distance.
When do the first and last buses from Pilsen to Prague leave?
The first bus to Prague leaves at 03:01, while the last one is scheduled at 12:01. The journey takes on average 1 hour and 3 minutes, but the fastest connections take only 1 hour.
Which bus companies serve the route Pilsen - Prague?
You can travel by bus from Pilsen to Prague with RegioJet.