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The route from Milan to Luxembourg is served daily by 12 bus departing from the stations of Milan (Lampugnano), Milan (San Donato), Milano (Sesto S.G.), Malpensa Terminal 2 and arriving to the stations of Luxembourg Kirchberg, Luxembourg Central Station, Luxembourg, P+R Bouillon.
The average duration of the journey is 13 h 38 min. The first bus leaves at 01:55. The last is at 22:30.

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