If the offers provided by buses do not suit your needs, trains and carpooling could represent a good alternative for this distance.
When the journey is so long, the bus takes much longer than other transportation. You can have a look at flights to London: by booking in advance you can find very cheap tickets!
What time do the busses to London leave?
The average duration of the journey is 43 hours and 36 minutes, but the fastest bus connections get you to London in 22 hours and 45 minutes. The first bus is scheduled at 09:01 and the last one at 22:01.
By bus from Milan to London: which companies offer the service?
Among the several partners of virail, you can also find Eurolines and FlixBus, offering buses from Milan to London.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.