Since the journey from Mainz to Frankfurt is not so long, the bus is a good solution, but if you are looking for more offers or departure times, you can also have a look at trains and carpooling solutions.
What time do the busses to Frankfurt leave?
To get from Mainz to Frankfurt by bus it will take you 34 hours and 5 minutes. The first departure is scheduled at 18:06, while the last bus is at 18:06.
Which bus companies are in service in the route Mainz - Frankfurt?
There are many companies cooperating with virail, among which also Eurolines SA with buses to Frankfurt.
Eurolines is one of the leader bus companies in Europe, with more than 350 connections in 23 countries. Among its services you can also find long-distance night buses.