If the offers provided by buses do not suit your needs, trains and carpooling could represent a good alternative for this distance.
When the journey is so long, the bus takes much longer than other transportation. You can have a look at flights to Marseille: by booking in advance you can find very cheap tickets!
When are the buses from Frankfurt to Marseille scheduled?
To get to Marseille from Frankfurt by bus, it will take you around 20 hours and 2 minutes, or even 17 hours and 20 minutes if you choose the fastest solutions. The first bus leaves Frankfurt at 13:05, while the last one is at 22:05.
Which bus lines can take you from Frankfurt to Marseille?
There are many companies cooperating with virail, among which also FlixBus with buses to Marseille.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.