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The route from Derby to Manchester is served daily by 52 bus departing from the stations of Derby East Midlands Airport, Derby, Derby Riverlights Bus Station and arriving to the stations of Manchester Central Bus Station, Manchester Miles Platting, Manchester Airport Bus Station, Manchester Coach Station.
The average duration of the journey is 4 h 45 min. The first bus leaves at 01:40. The last is at 22:05.

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