If the offers provided by buses do not suit your needs, trains and carpooling could represent a good alternative for this distance.
When the journey is so long, the bus takes much longer than other transportation. You can have a look at flights to Milan: by booking in advance you can find very cheap tickets!
When do the first and last buses from Cologne to Milan leave?
The average duration of the journey is 14 hours and 23 minutes, but the fastest bus connections get you to Milan in 12 hours and 40 minutes. The first bus is scheduled at 18:02 and the last one at 00:02.
By bus from Cologne to Milan: which companies offer the service?
Virail counts among its partners also FlixBus, with buses from Cologne to Milan.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.