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The route from Brussels to Prague is served daily by 75 bus departing from the stations of Brussels South (Gare Du Midi), Brussels-North Station, Brussels North Train Station, Gare Du Nord, Bruxelles Nord, Brussels Midi / Brussel Zuid East, Gare Du Midi, Bruxelles, Midi, Brussels Airport, Brussels Midi / Brussel Zuid West, Brussels Gare Du Midi and arriving to the stations of Prague Anděl, Prague ÚAN Florenc, Prague Florenc Central Bus Station, Prague Main Railway Station, ÚAN Florenc, Prague Wilsonova Bus Station, Prague, Florenc, Prague ,Hradčanská, Prague Vaclav Havel Airport Prague.
The average duration of the journey is 20 h 45 min. The first bus leaves at 02:00. The last is at 23:45.

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